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British Journal of Cancer Jun 2016Although meningioma is a benign tumour, it may cause significant morbidity. Obesity and diabetes are positively associated with meningioma. To evaluate the potential...
BACKGROUND
Although meningioma is a benign tumour, it may cause significant morbidity. Obesity and diabetes are positively associated with meningioma. To evaluate the potential effects of obesity-related prediagnostic glucose, triglycerides and cholesterol on meningioma and of prediagnostic meningioma on these biomarkers, we conducted a cohort study.
METHODS
We identified 41 355 individuals in the Apolipoprotein MOrtality RISk cohort with values for these biomarkers within 15 years before meningioma diagnosis, death, migration or the end of follow-up. We then estimated hazard ratios (HRs) and their interactions with time and age using Cox regression.
RESULTS
Meningioma was diagnosed in 181 women and 115 men whose median follow-up time was 7 years. Fasting serum glucose level was inversely related to meningioma among women (Ptrend=0.0006) but not men (Ptrend=0.24). Prediagnostic diabetes was inversely related to meningioma in both sexes combined (HR=0.45, 95% confidence interval (CI) 0.29-0.71), as was serum cholesterol within the year before diagnosis (HR=0.50, 95% CI 0.34-0.72).
CONCLUSIONS
Paradoxically, hyperglycaemia is inversely associated with meningioma in women. This finding does not necessarily negate the positive role of obesity or diabetes in meningioma development; rather, it may indicate that their effects depend on the stage of development. Furthermore, the prediagnostic tumour may reduce serum cholesterol levels.
Topics: Aged; Aged, 80 and over; Apolipoproteins; Biomarkers; Blood Glucose; Cholesterol; Cohort Studies; Diabetes Mellitus; Fasting; Female; Glucose; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Obesity; Proportional Hazards Models; Risk Factors; Triglycerides
PubMed: 27253176
DOI: 10.1038/bjc.2016.157 -
Journal of Neuro-oncology Jun 2016This systematic review evaluates relevant findings and methodologic aspects of studies on cognitive functioning in meningioma patients prior to and/or following surgery... (Review)
Review
This systematic review evaluates relevant findings and methodologic aspects of studies on cognitive functioning in meningioma patients prior to and/or following surgery with or without adjuvant radiotherapy. PubMed and Web of Science electronic databases were searched until December 2015. From 1012 initially identified articles, 11 met the inclusion criteria for this review. Multiple methodological limitations were identified which include the lack of pre-treatment assessments, variations in the number and types of neuropsychological tests used, the normative data used to identify patients with cognitive deficits, and the variety of definitions for cognitive impairment. Study results suggest that most of meningioma patients are faced with cognitive deficits in several cognitive domains prior to surgery. Following surgery, most of these patients seem to improve in cognitive functioning. However, they still have impairments in a wide range of cognitive functions compared to healthy controls. Suggestions are given for future research. Adequate diagnosis and treatment of cognitive deficits may ultimately lead to improved outcome and quality of life in meningioma patients.
Topics: Cognition; Humans; Meningeal Neoplasms; Meningioma
PubMed: 27048208
DOI: 10.1007/s11060-016-2115-z -
BMC Cancer Apr 2024Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers,...
Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn't yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients' age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact.
Topics: Humans; Meningioma; Glycated Hemoglobin; Meningeal Neoplasms; Hyperglycemia; Glucose
PubMed: 38632533
DOI: 10.1186/s12885-024-12243-4 -
Journal of Medical Case Reports Jun 2021Spontaneous subdural hematoma rarely presents with a hypervascular or malignant tumor but even less frequently in a benign tumor like meningioma. We encountered a... (Review)
Review
BACKGROUND
Spontaneous subdural hematoma rarely presents with a hypervascular or malignant tumor but even less frequently in a benign tumor like meningioma. We encountered a patient with acute subdural hematoma associated with benign meningioma. Here, we report this case along with a review of previous reports, especially focusing on their clinical features and possible bleeding mechanisms.
CASE PRESENTATION
A 53-year-old Asian woman presented with severe headache and progressive neurologic deterioration due to cerebral edema. The patient was submitted to open surgery for evacuation of the subdural hematoma and concurrent tumor removal on the ipsilateral parietal convexity. A hypervascular, encapsulated mass was identified during surgery and completely removed including the adjacent dura mater (Simpson grade 0). The tumor was histologically confirmed as an angiomatous meningioma (World Health Organization grade I). Her clinical course was uneventful after surgery.
CONCLUSIONS
Although meningiomas are commonly benign according to their histological traits, they can lead to spontaneous bleeding and cause neurologically unstable condition. Therefore, meningiomas need to be considered as a cause of spontaneous subdural hematoma if radiologically suspicious, which should be reflected by proper management for a positive outcome.
Topics: Brain Edema; Female; Hematoma, Subdural; Hematoma, Subdural, Acute; Humans; Meningeal Neoplasms; Meningioma; Middle Aged
PubMed: 34187580
DOI: 10.1186/s13256-021-02935-x -
Brain Pathology (Zurich, Switzerland) Jan 2021TERT promoter mutation (TERTp ) has a strong association to recurrence and has been suggested to act as a driver mutation for malignant transformation of WHO grade I and...
PURPOSE
TERT promoter mutation (TERTp ) has a strong association to recurrence and has been suggested to act as a driver mutation for malignant transformation of WHO grade I and II meningiomas. TERTp has been investigated in selected high-grade meningioma samples. The existence of TERTp across recurrent tumors in a population-based cohort needs to be investigated in order to identify when TERTp emerges across recurrent samples and to validate prognostic impact among WHO grade III tumors.
METHODS
We gathered material from a consecutive single-center cohort of 40 patients with malignant meningioma (WHO grade III) treated between 2000 and 2018, including specimens from primary and secondary malignant meningiomas with the corresponding earlier benign specimens and later malignant recurrences. In total 107 tumor samples were studied by Sanger sequencing for TERT promoter mutational status.
RESULTS
Seven of 40 patients (17.5%) harbored TERTp thus validating the incidence of TERTp in previous non-population-based cohorts. In 6/7 patients, the TERTp was present at initial surgery (WHO grade I-III) while in one patient the TERTp was found de novo when the meningioma became malignant. The incidences were 2/1.000.000/year for TERTp WHO grade III meningioma and 8/1.000.000/year for TERTp WHO grade III meningioma in our catchment area. We found a 1.7 times higher recurrence rate (CI 95% 0.65-4.44) and a 2.5 higher mortality rate per 10 person-years (CI 95% 1.01-6.19) for TERTp compared to TERTp .
CONCLUSION
TERTp can occur independently of malignant progression in meningioma and was most often present from the first tumor sample across recurring tumors. TERTp in WHO grade III may represent a marker of an aggressive subset of tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cohort Studies; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Point Mutation; Promoter Regions, Genetic; Telomerase; Young Adult
PubMed: 32805769
DOI: 10.1111/bpa.12892 -
Current Oncology Reports Jan 2021"Brain tumor is a bump in the road." Sheryl Crow a famous singer was quoted talking about her meningioma, a benign brain tumor that caused her to forget her lyrics. In... (Review)
Review
PURPOSE OF REVIEW
"Brain tumor is a bump in the road." Sheryl Crow a famous singer was quoted talking about her meningioma, a benign brain tumor that caused her to forget her lyrics. In this review, we focus on low-grade gliomas in adults and benign brain tumors, such as meningiomas, vestibular schwannomas, and pituitary tumors, since these individuals survive a long time and morbidity is a major issue.
RECENT FINDINGS
As per the NCI dictionary definition, cancer survivorship focuses on the health and well-being of a person with cancer from the time of diagnosis until the end of life. This includes the physical, mental, emotional, social, and financial effects of cancer that begin at diagnosis and continue through treatment and beyond. The survivorship experience also includes issues related to follow-up care (including regular health and wellness checkups), late effects of treatment, cancer recurrence, second cancers, and quality of life. Family members, friends, and caregivers are also considered part of the survivorship experience (NCI Dictionary: https://www.cancer.gov/publications/dictionaries/cancer-terms ).
Topics: Adenoma; Brain Neoplasms; Cancer Survivors; Combined Modality Therapy; Humans; Meningeal Neoplasms; Meningioma; Patient Care Team; Pituitary Neoplasms; Quality of Life; Survivorship
PubMed: 33471214
DOI: 10.1007/s11912-020-01004-8 -
Revue Medicale de Liege Nov 2011Conventional radiotherapy is known to be an effective treatment approach even for "benign" pathologies. However, this kind of treatment yields a high potential for side... (Review)
Review
Conventional radiotherapy is known to be an effective treatment approach even for "benign" pathologies. However, this kind of treatment yields a high potential for side effects. The Cyberknife, a robotic stereotactic radiotherapy device, enables to offset a large proportion of the disadvantages encountered with conventional radiotherapy essentially through the high precision of dose administration and sparing of healthy tissues. Therefore, it seems to be a treatment of choice in the approach of some benign intracranial diseases. We review published data on indications and outcome of Cyberknife for intracranial "non-malignant" disease.
Topics: Adenoma; Epilepsy, Temporal Lobe; Glomus Jugulare Tumor; Humans; Intracranial Arteriovenous Malformations; Meningeal Neoplasms; Meningioma; Pituitary Neoplasms; Quality of Life; Radiation Oncology; Radiosurgery; Radiotherapy Dosage; Treatment Outcome; Trigeminal Neuralgia
PubMed: 22216729
DOI: No ID Found -
Acta Neurochirurgica Nov 2022Meningioma is the most common primary CNS tumour. Most meningiomas are benign, and most patients are 65 years or older. Surgery is usually the primary treatment option....
BACKGROUND
Meningioma is the most common primary CNS tumour. Most meningiomas are benign, and most patients are 65 years or older. Surgery is usually the primary treatment option. Most prior studies on early surgical outcomes in older patients with meningioma are small, and there is a lack of larger population-based studies to guide clinical decision-making. We aimed to explore the risks for perioperative mortality and morbidity in older patients with meningioma and to investigate changes in surgical incidence over time.
METHODS
In this retrospective population-based study on patients in Sweden, 65 years or older with surgery 1999-2017 for meningioma, we used data from the Swedish Brain Tumour Registry. We analysed factors contributing to perioperative mortality and morbidity and used official demographic data to calculate yearly incidence of surgical procedures for meningioma.
RESULTS
The final study cohort included 1676 patients with a 3.1% perioperative mortality and a 37.6% perioperative morbidity. In multivariate analysis, higher age showed a statistically significant association with higher perioperative mortality, whereas larger tumour size and having preoperative symptoms were associated with higher perioperative morbidity. A numerical increased rate of surgical interventions after 2012 was observed, without evidence of worsening short-term surgical outcomes.
CONCLUSIONS
Higher mortality with increased age and higher morbidity risk in larger and/or symptomatic tumours imply a possible benefit from considering surgery in selected older patients with a growing meningioma before the development of tumour-related symptoms. This study further underlines the need for a standardized method of reporting and classifying complications from neurosurgery.
Topics: Humans; Aged; Meningioma; Neurosurgery; Retrospective Studies; Neurosurgical Procedures; Risk Factors; Incidence; Meningeal Neoplasms; Postoperative Complications; Treatment Outcome
PubMed: 35978200
DOI: 10.1007/s00701-022-05336-1 -
Journal of Clinical Neuroscience :... Dec 2020Primary intraosseous meningioma (PIM) is a rare subtype of extradural meningiomas that originates within bone. We aimed to characterize the clinical, radiographic, and...
Primary intraosseous meningioma (PIM) is a rare subtype of extradural meningiomas that originates within bone. We aimed to characterize the clinical, radiographic, and pathologic features of PIM and the resulting outcomes following resection. Herein we examined a retrospective case series of all patients with a pathologically confirmed WHO grade I PIM that were managed at one of three tertiary care centers. Patients with tumors that demonstrated extraosseous extension or involvement of the dura mater were excluded. The main outcomes included surgical safety and duration of local tumor control. Nine patients were identified with benign PIMs, presenting with headaches or painless enlarging subcutaneous masses if involving the calvarium or with neurologic deficits if involving the skull base, or otherwise incidentally identified. Surgery was pursued for symptomatic relief and/or tissue diagnosis. Lesions were evaluated by radiographic imaging - including sensitive detection by plain X-ray films - and definitive diagnosis ascertained by histopathological examination. Maximal resection of both calvarial and skull base lesions was safely tolerated. PIM represents a rare benign skull lesion, whose identification depends on the integration of radiographic findings with intraoperative findings and histopathological confirmation; it should be considered in the differential for slow-growing expansile intraosseous lesions of the skull.
Topics: Aged; Aged, 80 and over; Female; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Retrospective Studies; Skull Neoplasms; Treatment Outcome
PubMed: 33317736
DOI: 10.1016/j.jocn.2020.10.040 -
Thoracic Cancer Aug 2022Lung cancer has become a leading cause of cancer-related deaths. With the conventional use of low-dose spiral computed tomography (CT) in physical examinations, an... (Review)
Review
Lung cancer has become a leading cause of cancer-related deaths. With the conventional use of low-dose spiral computed tomography (CT) in physical examinations, an increasing number of small pulmonary nodules are screened. However, primary pulmonary meningiomas (PPMs) are rarely reported. Here, we report the case of a 64-year-old woman who had a CT scan during physical examination, which revealed three ground-glass-like opacity pulmonary nodules in both lungs. The patient underwent video-assisted thoracoscopic wedge resection of the right upper and lower lobes. Paraffin sections revealed pulmonary meningothelial-like and collagenous nodules in the right upper and lower lobes which stained as follows: EMA+, VIM+, SMA-, S-100-, CD34-, STAT6-, Ki-67+ (2%), and CgA-. Primary pulmonary meningiomas (PPMs) were finally diagnosed. PPM is a kind of rare and benign tumor. Surgery can provide a precise pathological examination, and patients can achieve an excellent prognosis after surgical resection.
Topics: Female; Humans; Lung Neoplasms; Meningeal Neoplasms; Meningioma; Middle Aged; Multiple Pulmonary Nodules; Neoplasms, Multiple Primary; Thoracic Surgery, Video-Assisted
PubMed: 35734847
DOI: 10.1111/1759-7714.14542